Global Phylogeography and Genomic Epidemiology of Carbapenem-Resistant blaOXA-232–Carrying Klebsiella pneumoniae Sequence Type 15 Lineage
Yuye Wu, Tian Jiang, Xianhong He, Jiayu Shao, Chenghao Wu, Weifang Mao, Huiqiong Jia, Fang He, Yingying Kong, Jianyong Wu, Qingyang Sun, Long Sun, Mohamed S. Draz, Xinyou Xie
, Jun Zhang
, and Zhi Ruan
Author affiliations: Zhejiang University School of Medicine Sir Run Run Shaw Hospital, Hangzhou, China (Y. Wu, T. Jiang, X. He, J. Shao, C. Wu, W. Mao, Y. Kong, X. Xie, J. Zhang, Z. Ruan); Wenzhou Medical University Affiliated Wenling Hospital, Taizhou, China (T. Jiang); Third People's Hospital of Xiaoshan District, Hangzhou (X. He, J. Shao); Shaoxing University Affiliated Hospital, Shaoxing, China (W. Mao); Zhejiang University School of Medicine First Affiliated Hospital, Hangzhou (H. Jia); Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, Hangzhou (H. Jia); Zhejiang Provincial People's Hospital, Hangzhou (F. He); Key Laboratory of Precision Medicine in Diagnosis and Monitoring Research of Zhejiang Province, Hangzhou (Y. Kong, X. Xie, J. Zhang, Z. Ruan); Zhejiang University School of Medicine Fourth Affiliated Hospital, Hangzhou (J. Wu); No. 903 Hospital of PLA Joint Logistic Support Force, Hangzhou (Q. Sun); Hangzhou Women's Hospital, Hangzhou (L. Sun); Case Western Reserve University School of Medicine, Cleveland, Ohio, USA (M.S. Draz); Cleveland Clinic, Cleveland (M.S. Draz)
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Figure 2
Figure 2. Genetic comparison of blaOXA-232–carrying plasmids (A) and virulence plasmids (B) recovered from Klebsiella pneumoniae isolate KP3295 from China with reference plasmids. A) Alignment of blaOXA-232–carrying plasmids pKP3295-5-OXA-232 (this study), pAI1235M_P5 (GenBank accession no. CP079136), pOXA-232_30929 (accession no. KX523904), pOXA-232 (accession no. JX423831), pBio45 (accession no. CP093855), pBio73 (accession no. CP093853), pBio3 (accession no. CP094228), p_dm730a_NDM5 (accession no. CP096174), and 730a-copy-1-OXA-232 (accession no. CP096173). We used pAI1235M_P5 as the reference plasmid. Red indicates antimicrobial resistance genes. B) Alignment of virulence plasmids pKP3295-1 (this study), pWSD411_2 (accession no. CP045675), pvirhs2_HS-3501_NODE2 (accession no. OM975892), p2579_1 (accession no. MK649822), kp7450_p1 (accession no. CP090469), pBA6740_1 (accession no. MK649823), pE16KP0290-1 (accession no. CP052259), pER17974.3 (accession no. CP059296), p2723–175k (accession no. CP072940), and pLVPK (accession no. AY378100). We used pLVPK as the reference plasmid. Red indicates virulence genes.
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