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Volume 29, Number 11—November 2023
Research

Neurologic Effects of SARS-CoV-2 Transmitted among Dogs

Dong-Hwi Kim1, Da-Yoon Kim1, Kyu-Sung Kim1, Sang-Hoon Han, Hyeon-Jeong Go, Jae-Hyeong Kim, Kyu-Beom Lim, Dong-Hun Lee, Joong-Bok Lee, Seung-Yong Park, Chang-Seon Song, Sang-Won Lee, Yang-Kyu Choi, Yeun-Kyung Shin, Oh-Kyu Kwon, Do-Geun KimComments to Author , and In-Soo ChoiComments to Author 
Author affiliations: Konkuk University, Seoul, South Korea (D.-H. Kim, D.-Y. Kim, S.-H. Han, H.-J. Go, J.-H. Kim, K.-B. Lim, D.-H. Lee, J.-B. Lee, S.-Y. Park, C.-S. Song, S.-W. Lee, Y.-K. Choi, I.-S. Choi); Korea Brain Research Institute, Daegu, South Korea (K.-S. Kim, D.-G. Kim); Daegu Gyeongbuk Institute of Science and Technology, Daegu (K.-S. Kim, D.-G. Kim); Animal and Plant Quarantine Agency, Gimcheon, South Korea (Y.-K. Shin, O.-K. Kwon); Konkuk University Zoonotic Diseases Research Center, Seoul (D.-H. Lee, J.-B. Lee, S.-Y. Park, C.-S. Song, S.-W. Lee, I.-S. Choi); KU Center for Animal Blood Medical Science, Seoul (I.-S. Choi)

Main Article

Figure 2

SARS-CoV-2 in the brain of dogs in study of the neurologic effects of SARS-CoV-2, showing transmission at an early stage of infection. A) Quantitative real-time PCR validation of the SARS-CoV-2 gene in the SARS-CoV-2–infected and contact groups of dogs, at each postinfection day. The dashed line indicates the regions where gene copy numbers of SARS-CoV-2 were considered negative. B) Representative fluorescent images of S1 protein (a marker of virus infection) and NeuN (a specific marker of neuronal cells) demonstrated SARS-CoV-2 infection in the canine brain sections of SARS-CoV-2–infected and contact dogs, at early and late days after infection. SARS-CoV-2–infected neuronal cells at the early stage of infection. At the late stage of infection, the presence of the virus appeared to diminish. Scale bars indicate 100 μm.

Figure 2. SARS-CoV-2 in the brain of dogs in study of the neurologic effects of SARS-CoV-2, showing transmission at an early stage of infection. A) Quantitative real-time PCR validation of the SARS-CoV-2 gene in the SARS-CoV-2–infected and contact groups of dogs, at each postinfection day. The dashed line indicates the regions where gene copy numbers of SARS-CoV-2 were considered negative. B) Representative fluorescent images of S1 protein (a marker of virus infection) and NeuN (a specific marker of neuronal cells) demonstrated SARS-CoV-2 infection in the canine brain sections of SARS-CoV-2–infected and contact dogs, at early and late days after infection. SARS-CoV-2–infected neuronal cells at the early stage of infection. At the late stage of infection, the presence of the virus appeared to diminish. Scale bars indicate 100 μm.

Main Article

1These authors contributed equally to this article.

Page created: September 18, 2023
Page updated: October 23, 2023
Page reviewed: October 23, 2023
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