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Volume 27, Number 4—April 2021
Research

Evolution of Sequence Type 4821 Clonal Complex Hyperinvasive and Quinolone-Resistant Meningococci

Mingliang Chen1Comments to Author , Odile B. Harrison1, Holly B. Bratcher, Zhiyan Bo, Keith A. Jolley, Charlene M.C. Rodrigues, James E. Bray, Qinglan Guo, Xi Zhang, Min ChenComments to Author , and Martin C.J. MaidenComments to Author 
Author affiliations: Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China (M. Chen, X. Zhang, M. Chen); University of Oxford, Oxford, UK (O.B. Harrison, H.B. Bratcher, Z. Bo, K.A. Jolley, C.M.C. Rodrigues, J.E. Bray, M.C.J. Maiden); Fudan University, Huashan Hospital, Shanghai (Q. Guo)

Main Article

Figure 7

Circular genome map of CC4821 Neisseria meningitidis genome 053442 with BLAST (https://blast.ncbi.nlm.nih.gov/Blast.cgi) comparisons to the genomes of other sublineages. The innermost rings show guanine and cytosine (G+C) content (black) and G+C skew (negative in purple, positive in green) of genome 053442. The 4 outer rings show BLAST comparisons (using BLASTn and an E-value cutoff of 10.0) to the complete genome sequence of 053442 (red), Nm449 (green), Nm205 (pale blue), and Nm323 (blue); shading on rings indicates percentage identity as indicated in the key. Labels around the outer ring refer to the 46 HGT events involving 149 unique loci that are labeled with their possible donor strain. Red text indicates loci related to most common donors; blue text indicates those with serogroup A lineage donors. CC, clonal complex; HGT, horizontal gene transfer; Nm, N. meningitidis; ST, sequence type.

Figure 7. Circular genome map of CC4821 Neisseria meningitidis genome 053442 with BLAST (https://blast.ncbi.nlm.nih.gov/Blast.cgi) comparisons to the genomes of other sublineages. The innermost rings show guanine and cytosine (G+C) content (black) and G+C skew (negative in purple, positive in green) of genome 053442. The 4 outer rings show BLAST comparisons (using BLASTn and an E-value cutoff of 10.0) to the complete genome sequence of 053442 (red), Nm449 (green), Nm205 (pale blue), and Nm323 (blue); shading on rings indicates percentage identity as indicated in the key. Labels around the outer ring refer to the 46 HGT events involving 149 unique loci that are labeled with their possible donor strain. Red text indicates loci related to most common donors; blue text indicates those with serogroup A lineage donors. CC, clonal complex; HGT, horizontal gene transfer; Nm, N. meningitidis; ST, sequence type.

Main Article

1These authors contributed equally to this article.

Page created: March 02, 2021
Page updated: March 18, 2021
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