Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 23, Number 8—August 2017
Dispatch

Clonal Expansion of New Penicillin-Resistant Clade of Neisseria meningitidis Serogroup W Clonal Complex 11, Australia

Shakeel MowlaboccusComments to Author , Keith A. Jolley, James E. Bray, Stanley Pang, Yung Thin Lee, Jane D. Bew, David J. Speers, Anthony D. Keil, Geoffrey W. Coombs, and Charlene M. Kahler
Author affiliations: University of Western Australia, Perth, Western Australia, Australia (S. Mowlaboccus, D.J. Speers, C.M. Kahler); University of Oxford, Oxford, UK (K.A. Jolley, J.E. Bray); Murdoch University, Murdoch, Western Australia, Australia (S. Pang, Y.T. Lee, G.W. Coombs); Fiona Stanley Hospital, Perth (S. Pang, G.W. Coombs); Queen Elizabeth II Medical Centre, Perth (J.D. Bew, D.J. Speers); Princess Margaret Hospital for Children, Perth (A.D. Keil); Telethon Kids Institute, Perth (C.M. Kahler)

Main Article

Figure 2

Phylogenetic reconstruction by using an unrooted neighbor-net algorithm of core genomes of clonal complex 11 Neisseria meningitidis strains with serogroup W capsules (MenW:cc11), Western Australia, Australia, January 2013–December 2016. Blue circles indicate isolates in cluster A from Western Australia; red circles indicate isolates in cluster B from Western Australia; gray circle indicates ExNm672, a strain isolated from a traveler; open squares indicate the 5 MenW:cc11 isolates in the PubMLST

Figure 2. Phylogenetic reconstruction by using an unrooted neighbor-net algorithm of core genomes of clonal complex 11 Neisseria meningitidis strains with serogroup W capsules (MenW:cc11), Western Australia, Australia, January 2013–December 2016. Blue circles indicate isolates in cluster A from Western Australia; red circles indicate isolates in cluster B from Western Australia; gray circle indicates ExNm672, a strain isolated from a traveler; open squares indicate the 5 MenW:cc11 isolates in the PubMLST database (http://pubmlst.org/neisseria) that contains the penA_253 allele; and black squares indicate reference MenW:cc11 strains, isolated after 2010, as described by Lucidarme et al. (8). M7124 is the Hajj clone isolated in Saudi Arabia in 2000. Numbers in parentheses indicate PubMLST numbers of reference isolates. Scale bar indicates nucleotide substitutions per site.

Main Article

References
  1. Maiden  MC, Bygraves  JA, Feil  E, Morelli  G, Russell  JE, Urwin  R, et al. Multilocus sequence typing: a portable approach to the identification of clones within populations of pathogenic microorganisms. Proc Natl Acad Sci U S A. 1998;95:31405. DOIPubMedGoogle Scholar
  2. Meningitis control in countries of the African meningitis belt, 2015. Wkly Epidemiol Rec. 2016;91:20916.PubMedGoogle Scholar
  3. Caugant  DA, Maiden  MC. Meningococcal carriage and disease—population biology and evolution. Vaccine. 2009;27(Suppl 2):B6470. DOIPubMedGoogle Scholar
  4. Mowlaboccus  S, Perkins  TT, Smith  H, Sloots  T, Tozer  S, Prempeh  LJ, et al. Temporal changes in BEXSERO® antigen sequence type associated with genetic lineages of Neisseria meningitidis over a 15-year period in Western Australia. PLoS One. 2016;11:e0158315. DOIPubMedGoogle Scholar
  5. Martin  NV, Ong  KS, Howden  BP, Lahra  MM, Lambert  SB, Beard  FH, et al.; Communicable Diseases Network Australia MenW Working Group. Rise in invasive serogroup W meningococcal disease in Australia 2013-2015. Commun Dis Intell Q Rep. 2016;40:E4549.PubMedGoogle Scholar
  6. Carville  KS, Stevens  K, Sohail  A, Franklin  LJ, Bond  KA, Brahmi  A, et al. Increase in meningococcal serogroup W disease, Victoria, Australia, 2013–2015. Emerg Infect Dis. 2016;22:17857. DOIPubMedGoogle Scholar
  7. Ladhani  SN, Beebeejaun  K, Lucidarme  J, Campbell  H, Gray  S, Kaczmarski  E, et al. Increase in endemic Neisseria meningitidis capsular group W sequence type 11 complex associated with severe invasive disease in England and Wales. Clin Infect Dis. 2015;60:57885. DOIPubMedGoogle Scholar
  8. Lucidarme  J, Hill  DM, Bratcher  HB, Gray  SJ, du Plessis  M, Tsang  RS, et al. Genomic resolution of an aggressive, widespread, diverse and expanding meningococcal serogroup B, C and W lineage. J Infect. 2015;71:54452. DOIPubMedGoogle Scholar
  9. Oppenheim  BA. Antibiotic resistance in Neisseria meningitidis. Clin Infect Dis. 1997;24(Suppl 1):S98101. DOIPubMedGoogle Scholar
  10. Zapun  A, Morlot  C, Taha  MK. Resistance to β-lactams in Neisseria ssp due to chromosomally encoded penicillin-binding proteins. Antibiotics (Basel). 2016;5:E35. DOIPubMedGoogle Scholar
  11. Turner  PC, Southern  KW, Spencer  NJ, Pullen  H. Treatment failure in meningococcal meningitis. Lancet. 1990;335:7323. DOIPubMedGoogle Scholar
  12. Jolley  KA, Maiden  MC. BIGSdb: Scalable analysis of bacterial genome variation at the population level. BMC Bioinformatics. 2010;11:595. DOIPubMedGoogle Scholar
  13. Bond  KA, Stevens  K, Bulach  D, Carville  K, Ong  KS, Howden  BP. Rising incidence of invasive meningococcal disease caused by Neisseria meningitidis serogroup W in Victoria. Med J Aust. 2016;204:2656. DOIPubMedGoogle Scholar
  14. Bratcher  HB, Corton  C, Jolley  KA, Parkhill  J, Maiden  MC. A gene-by-gene population genomics platform: de novo assembly, annotation and genealogical analysis of 108 representative Neisseria meningitidis genomes. BMC Genomics. 2014;15:1138. DOIPubMedGoogle Scholar
  15. Harrison  OB, Clemence  M, Dillard  JP, Tang  CM, Trees  D, Grad  YH, et al. Genomic analyses of Neisseria gonorrhoeae reveal an association of the gonococcal genetic island with antimicrobial resistance. J Infect. 2016;73:57887. DOIPubMedGoogle Scholar

Main Article

Page created: July 17, 2017
Page updated: July 17, 2017
Page reviewed: July 17, 2017
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external