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Monomethyl aniline
May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
CAS number: 100–61–8
NIOSH REL: 0.5 ppm (2 mg/m3) TWA [skin]
Current OSHA PEL: 2 ppm (9 mg/m3) TWA [skin]
1989 OSHA PEL: 0.5 ppm (2 mg/m3) TWA [skin]
1993-1994 ACGIH TLV: 0.5 ppm (2.2 mg/m3) TWA [skin]
Description of substance: Yellow to light-brown liquid with a weak, ammonia-like odor.
LEL: . . . Unknown
Original (SCP) IDLH: 100 ppm
Basis for original (SCP) IDLH: The chosen IDLH is based on an analogy with aniline which has an IDLH of 100 ppm.
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA:
Lethal dose data:
| Species | Reference | Route | LD50 (mg/kg) | LDLo (mg/kg) | Adjusted LD | Derived value |
|---|---|---|---|---|---|---|
| RabbitG. pig | Treon et al. 1949von Oettingen 1941 | oraloral | ———- | 2801,200 | 439 ppm1,883 ppm | 44 ppm188 ppm |
Other animal data: It has been reported that a dog survived 50 seven-hour exposures to 86 ppm [Treon et al. 1949].
Human data: None relevant for use in determining the revised IDLH.
| Revised IDLH: 100 ppm [Unchanged]Basis for revised IDLH: Based on animal subchronic inhalation toxicity data [Treon et al. 1949] and an analogy to aniline which has a revised IDLH of 100 ppm, the original IDLH for monomethyl aniline (100 ppm) is not being revised at this time. |
REFERENCES:
1. Treon JF, Deichmann WB, Sigmon HE, Wright H, Witherup SO, Heyroth FF, Kitzmiller KV, Keenan C [1949]. The toxic properties of xylidine and monomethylaniline. I. The comparative toxicity of xylidine and monomethylaniline when administered orally or intravenously to animals or applied on their skin. J Ind Hyg Toxicol 31:1-20.
2. von Oettingen WF [1941]. The aromatic amino and nitro compounds, their toxicity and potential dangers. Public Health Bulletin 271:16.