Events
Special Seminar: Public Health Genomics: "Closing the Gap Between Human Genome Discoveries and Population Health"
Organized by Muin J. Khoury, M.D., Ph.D.
Office of Public Health Genomics
Centers for Disease Control and Prevention
Sponsor: National Cancer Institute
Cosponsors: National Human Genome Research Institute, National Institute for Child Health and Development, and the Office of Behavioral and Social Sciences ResearchIn 2007, the CDC Office of Public Health Genomics in collaboration with NCI conducted a monthly seminar series (PDF 506.34 KB) exploring various topics at the intersection of genomics, medicine and public health. The series explored the contributions of the multidisciplinary field of "public health genomics" to the translation of genomic discoveries into population health benefits. Webcasts, slides and selected readings are available below.
Session 1: January 18, 2007, 1-3pm, ENVISION-Koger Center, Williams Bldg, Room 1805
What is “public health genomics” and why should we care? An overview of the series
Speaker: Muin J. Khoury, CDC (slides (PDF 3.64MB)) (videocast (49:56 min))
"Omics" 101 for medicine and public health
Speaker: Stephen Chanock, NCIPDF(1.02GB)
Discussion: (slides (PDF 6.19MB)) (videocast (1:08 min))
- Burke W, Khoury MJ, Stewart A, Zimmern RL. The path from genome-based research to population health: Development of an international public health genomics network (PDF 1.12MB). Genetics In Medicine 2006; 8(7):451-8.
- Genome-based Research and Population Health (PDF 1.15MB). Report of an expert workshop held at the Rockefeller Foundation Study and Conference Centre Bellagio, Italy, 14 - 20 April 2005.
Session 2: February 15, 2007, 1-3 pm, ENVISION-Koger Center, Williams Bld, Room 1802/05
How do we assess the contribution of complex genotypes and gene-environment interaction to the population burden of common diseases?
Introduction Speaker: Muin J. Khoury, CDC
(slides (PDF 642KB))
Cancer genetic epidemiology: what has worked and what has not worked?
Speaker: Robert Hoover, NCI
(slides (PDF 925KB)) (videocast (56:12 min) including introduction by Muin Khoury)
Speaker: Teri Manolio, NHGRI (slides (PDF 1.29MB)) (videocast (34:22 min))
- Manolio TA, Bailey-Wilson JE, and Collins FS. Genes, environment and the value of prospective cohort studies (PDF 440KB). Nature 2006;7:812-20.
- Willett WC, et al. Commentary: Merging and emerging cohorts (PDF 249KB). Nature 2007;445:257-8.
- Collins FS, and Manolio TA. Commentary: Necessary but not sufficient (PDF 110KB). Nature 2007.
- Hoover RN. The Evolution of Epidemiologic Research: From Cottage Industry to "Big" Science (PDF 393KB). Epidemiology 2007;18(1):13-7.
Session 3: March 12, 2007, 1-3 pm, ENVISION-Koger Center, Williams Bld, Room 1802/05
What is the role of behavioral and social sciences in translating genetic research into population health benefits?
Introduction Speaker: Muin J. Khoury, CDC
(slides (PDF 364KB))
Beyond Nature/Nurture: transdisciplinary approach to genomic, behavioral and social science research
Speaker: David Abrams, Director NIH OBSSR
(slides (PDF 2.9MB)) (videocast (57:53 min) including introduction by Muin Khoury)
Using genomics to change health behavior
Speaker: Colleen McBride, NHGRI (slides (PDF 2.9MB)) (videocast (48:12 min))
- McBride, CM. Blazing a trail: A public health research agenda in genomics and chronic disease (PDF 181KB). Preventing Chronic Disease 2005;2(2):1-5.
- Moffitt TE, Caspi A, Rutter M. Interactions in psychopathology: Concepts, research strategies, and implications for research, intervention, and public understanding of genetics (PDF 229KB). Perspective Psychological Science 2006;1(1):5-27.
Session 4: April 19, 2007, 1-3 pm, ENVISION-Koger Center, Williams Bld, Room 2103
Knowledge integration in public health genomics: evaluation of the epidemiologic evidenceGrading cumulative evidence, integrating biology, and developing online knowledge base
Speaker: Muin J. Khoury, CDC (slides (PDF 1.85MB))
(videocast (45:45 min))
Cancer example: Genetic polymorphisms, environmental exposures and bladder cancer
Speaker: Nat Rothman, NCI (slides (PDF 734KB))
(videocast (52:33 min))
- García-Closas M, Malats N, Silverman D, Dosemeci M, Kogevinas M, Hein DW, Tardón A, Serra C, Carrato A, García-Closas R, Lloreta J, Castaño-Vinyals G, Yeager M, Welch R, Chanock S, Chatterjee N, Wacholder S, Samanic C, Torá M, Fernández F, Real FX, Rothman N. NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analyses (PDF 159KB). Lancet 2005; 366:649-59.
- Ioannidis JPA, Gwinn M, Little J, Higgins JPT, Bernstein JL, Boffetta P, Bondy M, Bray MS, Brenchley PE, Buffler PA, Casas JP, Chokkalingam A, Danesh J, Smith GD, Dolan S, Duncan R, Gruis NA, Hartge P, Hashibe M, Hunter DJ, Jarvelin MR, Malmer B, Maraganore DM, Newton-Bishop JA, O'Brien TR, Petersen G, Riboli E, Salanti G, Seminara D, Smeeth L, Taioli E, Timpson N, Uitterlinden AG, Vineis P, Wareham N, Winn DM, Zimmern R, Khoury MJ. A road map for efficient and reliable human genome epidemiology (PDF 124KB). Nature Genetics 2006; 38:3-5.
- Lin BK, Clyne M, Walsh M, Gomez O, Yu W, Gwinn M, Khoury MJ. Tracking the Epidemiology of Human Genes in the Literature: The HuGE Published Literature Database (PDF 59KB). Am J Epidemiol. 2006 Jul 1;164(1):1-4.
- Seminara D, Khoury MJ, O'Brien TR, Manolio T, Gwinn ML, Little J, Higgins JP, Bernstein JL, Boffetta P, Bondy M, Bray MS, Brenchley PE, Buffler PA, Casas JP, Chokkalingam AP, Danesh J, Davey SG, Dolan S, Duncan R, Gruis NA, Hashibe M, Hunter D, Jarvelin MR, Malmer B, Maraganore DM, Newton-Bishop JA, Riboli E, Salanti G, Taioli E, Timpson N, Uitterlinden AG, Vineis P, Wareham N, Winn DM, Zimmern R, Ioannidis JP. The emergence of networks in human genome epidemiology: challenges and opportunities (PDF 291KB). Epidemiology 2007; 18(1):1-8.
Session 5: May 17, 2007, 1-3 pm, ENVISION-Koger Center, Williams Bld, Room 2103
Knowledge integration in public health genomics: evaluation of genetic and genomic testsA public health framework for genetic test evaluation
Speaker: Muin J. Khoury, CDC (slides (PDF 1.5MB)) (videocast (32:28 min))
Evidence-based Guidelines for the Evaluation
of Genomic Applications in Practice and Prevention
Speaker: Al Berg, CDC (slides (PDF 3.8MB)) (videocast (32:27 min))
- CDC Information on Genetic Testing (featuring ACCE)
- Evaluation of Genomic Applications in Practice and Prevention (EGAPP) Initiative
- Janssens AC, Gwinn M, Valdez R, Narayan KM, Khoury MJ. Predictive genetic testing for type 2 diabetes (PDF 71KB). BMJ 2006 ;333(7567):509-10.
- Grosse SD, Khoury MJ. What is the clinical utility of genetic testing? (PDF 110KB) Genet Med 2006;8(7):448-50.
Session 6: July 26, 2007, 1-3 pm, ENVISION-Koger Center, Williams Bld, Room 1802/05
But how do we translate new genetic knowledge into practice?
How do we actually translate guidelines into action?
Introduction
Speaker: Muin J. Khoury, CDC
(slides (PDF 1.4MB))
Speaker, Jon Kerner, NCI
(slides (PDF 1.6MB)) (videocast (51 min))
What is the role of professional organizations, consumers, oversight and regulation?
Speaker: Kathy Hudson (PDF 30KB), Genetics and Public Policy Center, Johns Hopkins University (slides (PDF 2.4MB)) (videocast (36:58 min))
- Hudson K. 2007. Prohibiting genetic discrimination (PDF 195KB). New England Journal of Medicine 356(20): 2021-2023.
- Javitt G. and Hudson K. 2007. The right prescription for personalized genetic medicine (PDF 161KB). Personalized Medicine 4(2): 115-118.
- Hudson K., Murphy J., Kaufman D., Javitt G., Katsanis S., and Scott J. 2006. Oversight of US genetic testing laboratories (PDF 195KB). Nature Biotechnology 24(9): 1083-1090.
- Kerner J.F,Guirguis-Blake J., Hennessy K.D., Brounstein P.J., Vinson C., Schwartz R.H., Myers B.A., and Briss P. 2005. Translating research into improved outcomes in comprehensive cancer control (PDF 274KB). Cancer Causes and Control 16(Suppl. 1): 27-40.
- Kerner J.F. 2006. Knowledge translation versus knowledge integration: a "funder’s" perspective (PDF 187KB). The Journal of Continuing Education in the Health Professions Vol. 26, 72-80.
- Park E.R., Kleimann S., Shields A.E., and Pelan J.A. 2007. Anticipating clinical integration of genetically tailored tobacco dependence treatment: Perspectives of primary care physicians (PDF 255KB) Nicotine & Tobacco Research, 9(2), 271 - 279
- Lerman C. and Shields A.E. 2004. Genetic testing for cancer susceptibility: the promise and the pitfalls (PDF 258KB) Nature Reviews Cancer, 4(March), 235 - 241
- Parthasarathy S. 2005. Architectures of genetic medicine: comparing genetic testing for breast cancer in the USA and the UK (PDF 2.8MB). Social Studies of Science 35(1) 5-40
Session 7: September 20, 2007, 1-3 pm, ENVISION-Koger Center, Williams Bld, Room 1802/05
How do we monitor the impact of genomics on population health?Role of public health agencies in assessing and assuring appropriate use of genomics in population health
Speaker: Muin J. Khoury, CDC (slides (PDF 3MB)) (videocast (32:37 min))
Applied research for genomic applications in clinical practice
Speaker: Louise Wideroff, NCI (slides (PDF 135KB)) (videocast (39:43 min))
- Beskow L, Khoury MJ, Baker TG, Thrasher J. The Integration of Genomics into Public Health Research, Policy, and Practice in the United States. Community Genetics 2001;4:2-11.
- Khoury MJ, McCabe L, McCabe ERB. Population screening in the age of genomic medicine (PDF 118KB). New Engl J Med 2003;348:50-58.
- Lindegren ML, Lyn S, Moore CA. The role of human genomics in acute public health investigations: current practice and future strategies. CDC Genomics and Population Health Report 2005.
- Goddard KAB, Moore C, Ottman D, Bradley L,Khoury MJ. Awareness and use of direct to consumer nutrigenomic tests, United States, 2006 (PDF 333KB). Genet Med 2007;9:510-517.
- Meropol NJ, Schulman KA. 2007. Cost of Cancer Care: Issues and Implications (PDF 135KB). J Clin Oncol 25(2), 180-186.
- Genetic Tests for Cancer. Prepared for the Agency for Healthcare Research and Quality (PDF 487KB).
- Hall MJ, Olopade OI. 2006. Disparities in Genetic Testing: Thinking Outside the BRCA Box (PDF 105KB). J Clin Oncol 24(14), 2197-2203.
Session 8: October 18, 2007, 1-3 pm, ENVISION-Koger Center, Williams Bld, Room 1802/05
Can we use family history as a tool for disease prevention and public health? Introduction Speaker: Muin J. Khoury, CDC (slides (PDF 70KB))
The Surgeon General family history initiative: why is family history important in the genomics age?
Speaker: Alan Guttmacher, NHGRI (slides (PDF 1.23MB))(videocast (35:49 min))
Speaker: Paula Yoon, CDC (slides (PDF 1.62B))(videocast (48:36 min))
- Guttmacher AE, Collins FS, Carmona RH. The family history--more important than ever (PDF 71KB). New England Journal of Medicine 2004; Nov 25; 351(22):2333-6.
- Valdez R, Yoon PW, Liu T, Khoury MJ. Family history and prevalence of diabetes in the US population: 6-year results from the National Health and Nutrition Examination Survey (NHANES, 1999 2004) (PDF 120KB). Diabetes 2007; Jul 31 [Epub ahead of print]
- Valdez R, Greenlund KJ, Khoury MJ, Yoon PW. Is family history a useful tool for detecting children at risk for diabetes and cardiovascular diseases? A public health perspective (PDF 272KB). Pediatrics 2007 Sep; 120 Suppl 2: S78-86.
- Scheuner MT, Whitworth WC, McGruder H, Yoon PW, Khoury MJ. Familial risk assessment for early-onset coronary heart disease (PDF 103KB). Genetics in Medicine 2006 Aug; 8(8):525-31.
Session 9: November 29, 2007, 1-3 pm, ENVISION-Koger Center, Williams Bld, Room 1802/05
Genomics and the schism between basic sciences, medicine and public healthGenomic medicine and health disparities
Speaker: Charles Rotimi, Howard University (slides (PDF 1.02MB)) (videocast (48:36 min))
Speaker: Muin J. Khoury, CDC (slides (PDF 2.29 MB) (videocast (40:33 min))
- Khoury MJ, Gwinn M, Burke W, Bowen S, Zimmern R. Will Genomics Widen or Help Heal the Schism Between Medicine and Public Health? (PDF 117KB) Am J Prev Med 2007; 33(4); 310-3117.
- Scheumer MT, Whitworth WC, McGruder H, Yoon PW, Khoury MJ. Familial risk assessment for early-onset coronary heart disease (PDF 324KB). Genet Med 2007:9(10):665-674.
- Foster MW and Sharp RR. Beyond race: towards a whole-genome perspective on human populations and genetic variation (PDF 198KB). Nat Rev Genet 2004;5(10):790-796.
- Sabeti PC, Varilly P, Fry B, Lohmueller J, Hostetter E, Cotsapas C, Xie X, Byrne EH, McCarroll SA, Gaudet R, Schaffner SF, Lander ES, & The International HapMap Consortium. Genome-wide detection and characterization of positive selection in human populations (PDF 1MB). Nature 2007;449(7164):913-913.
- Rotimi CN. Are medical and nonmedical users of large-scale genomic markers conflating genetics and 'race'? (PDF 118KB). Nat Genet 36(11 Suppl):S43-47.
- Genes, drugs and race (PDF 52KB). Nat Genet 2001;29(3):239-240.
- Duster T. Race and Reification in Science (PDF 110KB). Science 2005;307(5712):1050-1051.
- Slicing soup (PDF 62KB). Nat Biotechnol 2002;20(7):637.
- Garcia RS. The Misuse of Race in Medical Diagnosis (PDF 225KB). Pediatrics 2004;113:1394-1395.
- Sankar P, Cho MK, Mountain J. Race and Ethnicity in Genetic Research (PDF 127KB). Am J Med Genet A 2007;143(9):961-970.
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